Alternatives to Common Medications: Better Options for Fertility, ED, TB, and More

When a medication isn’t working, costs too much, or gives you side effects, you don’t just need a new prescription—you need a better alternative, a different treatment option that delivers similar or better results with fewer downsides. Also known as substitute therapy, an alternative isn’t just a backup—it’s often the smarter choice if you know what to look for. Whether you’re dealing with high prolactin, erectile dysfunction, or a stubborn infection, there’s almost always another option that fits your body, budget, or lifestyle better than the first drug your doctor suggested.

For example, if you’ve tried Fertomid (Clomiphene), a common ovulation stimulant used for infertility. Also known as Clomiphene citrate, it but it didn’t work, letrozole, an aromatase inhibitor now preferred for PCOS-related infertility. Also known as Femara, it might be more effective with fewer risks. Or if Abhigra (Sildenafil), a PDE5 inhibitor used to treat erectile dysfunction. Also known as generic Viagra, it gives you headaches, vardenafil, a longer-lasting ED medication with lower rates of visual side effects. Also known as Levitra, it could be your next move. Even Ethionamide, a second-line TB drug with harsh side effects. Also known as Trecator SC, it has better alternatives today, like bedaquiline or pretomanid, that are easier on the body and more effective against drug-resistant strains.

You’ll find similar comparisons for beta blockers, medications used to control blood pressure and heart rate. Also known as cardioselective blockers, they like Zebeta versus metoprolol, or dapoxetine, the only FDA-approved pill for premature ejaculation. Also known as Duratia, it versus SSRIs or topical sprays. Even for things like nausea from opioids or yeast infections tied to allergies, there are practical, science-backed alternatives most people never hear about.

This collection doesn’t just list drugs—it shows you how they stack up. You’ll see real comparisons: which ones work faster, which cost less, which have fewer side effects, and which are actually better for your specific condition. No fluff. No marketing. Just clear, direct comparisons so you can ask the right questions next time you talk to your doctor. Whether you’re managing fertility, pain, infections, or chronic illness, the right alternative could make all the difference. Below, you’ll find detailed breakdowns of exactly those options—so you’re never stuck with the first choice.